Accuracy of immunochemical faecal occult blood test for colorectal cancer: meta-analysis / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 392-398, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-291631
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the accuracy of immunological fecal occult blood test (iFOBT) for detection of colorectal cancer (CRC).</p><p><b>METHODS</b>A total of 1 197 studies published before June 2014 were selected from PubMed and Embase and 17 of which were finally included in this meta-analysis. A bivariate mixed-effects models was used for overall value merging and heterogeneity testing. In addition to the overall sensitivity and specificity, the analyses were also performed among certain subgroups, including a "colonoscopy group" (all were referred for colonoscopy diagnosis regardless screening results) and a "follow-up group" (only the screening positive were referred and all were then followed up), a qualitative group and a quantitative group (classified by the way of iFOBT result reading).</p><p><b>RESULTS</b>A total of 161 502 subjects aged from 48 to 63 years were included in the analysis. IFOBT had an overall integrated sensitivity of 0.85 (95% CI 0.79-0.89) (heterogeneity test Q = 59.67, P < 0.001) and an overall integrated specificity of 0.93 (95% CI 0.92-0.94) (heterogeneity test Q = 1 722.53, P < 0.001) for detection of CRC. In the subgroup analysis, it was found that in the "colonoscopy group" and in the "follow-up group", the sensitivity were 0.81 (95%CI 0.73-0.87) and 0.88 (95% CI 0.81-0.92), respectively; the specificity were 0.92 (95% CI 0.89-0.93) and 0.95 (95% CI 0.94-0.96), respectively. It was also found that in the qualitative group and the quantitative group, the sensitivity were 0.84 (95% CI 0.76-0.90) and 0.86 (95% CI 0.78-0.92), respectively; the specificity were 0.94 (95% CI 0.91-0.96) and 0.93 (95% CI 0.91-0.94), respectively.</p><p><b>CONCLUSION</b>IFOBT had high overall sensitivity and specificity for detecting colorectal cancer.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Colorretais
/
Programas de Rastreamento
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Sensibilidade e Especificidade
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Colonoscopia
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Testes Hematológicos
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Sangue Oculto
Tipo de estudo:
Estudo diagnóstico
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Pesquisa qualitativa
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Estudo de rastreamento
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Revisão sistemática
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Preventive Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo