Evaluation of CD4+ CD25+ regulatory T cells in the peripheral blood of recurrent spontaneous abortion patients / 中华男科学杂志
National Journal of Andrology
; (12): 1106-1108, 2008.
Article
em Zh
| WPRIM
| ID: wpr-292444
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of CD4+ CD25+ regulatory T cells (CD4+ CD25+ Tr) in the pathogenesis of recurrent spontaneous abortion.</p><p><b>METHODS</b>Peripheral blood samples were collected from 29 women with unexplainable recurrent spontaneous abortion (the URSA group) and another 20 with normal pregnancy (the control group). The percentage of CD4+ CD25+ Tr in the peripheral blood was measured by flow cytometry.</p><p><b>RESULTS</b>The rate of CD4+ CD25bright Tr in the URSA patients ([1.98 +/- 0.96]%) was significantly lower than that in the control group ([3.21 +/- 1.25]%, P < 0.05), while the percentages of CD4+ CD25+ and CD4+ CD25dim and the ratio of CD4+ CD25bright/CD4+ were not significantly different between the two groups (P > 0.05).</p><p><b>CONCLUSION</b>URSA might be associated with the decreased percentage of CD4+ CD25bright Tr, which plays an important role in fetomaternal immunologic tolerance.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Sangue
/
Antígenos CD4
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Estudos de Casos e Controles
/
Aborto Espontâneo
/
Aborto Habitual
/
Linfócitos T Reguladores
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Alergia e Imunologia
/
Subunidade alfa de Receptor de Interleucina-2
/
Citometria de Fluxo
/
Tolerância Imunológica
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Pregnancy
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2008
Tipo de documento:
Article