Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the protective effect of Ligustrazine on IR after local cerebral ischemia of rat.</p><p><b>METHOD</b>Models of rat IR after local cerebral ischemia were prepared by electrocagulation of the middle cerebral artery, and changes of serum insulin, tomer necrosis factor-alpha (TNF-alpha), plasma endothelin-1 (ET-1), nitric oxide (NO) and nitric oxide synthase (NOS) were observed 2 weeks after the ischemia.</p><p><b>RESULT</b>Ligustrazine could significantly reduce serum insulin (P < 0.01), the content of plasma ET-1 (P < 0.01) and serum TNF-alpha (P < 0.01), the activity of brain tissue NO and NOS (P < 0.01). The drug also increased insulin sensitivity indexes (ISI).</p><p><b>CONCLUSION</b>The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.</p>