Adaptive designs for clinical trial / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>In order to provide readers with general concepts and methodology on adaptive designs for clinical trial.</p><p><b>METHODS</b>Definition of adaptive designs for clinical trial and basic idea of adaptive adjustment were introduced through an example.</p><p><b>RESULTS</b>The relationship between adaptive designs and group sequential design was summarized. Ways to embody two basic statistical rules of clinical trial under adaptive adjustments setting were also introduced.</p><p><b>CONCLUSION</b>Adaptive designs provided clinical trial with a great flexibility, which could greatly improve the efficiency of clinical trial.</p>