Recent progress in the study of methylated tumor suppressor genes in gastric cancer / 癌症
Chinese Journal of Cancer
; (12): 31-41, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-294461
Biblioteca responsável:
WPRO
ABSTRACT
Gastric cancer is one of the most common malignancies and a leading cause of cancer mortality worldwide. The pathogenesis mechanisms of gastric cancer are still not fully clear. Inactivation of tumor suppressor genes and activation of oncogenes caused by genetic and epigenetic alterations are known to play significant roles in carcinogenesis. Accumulating evidence has shown that epigenetic silencing of the tumor suppressor genes, particularly caused by hypermethylation of CpG islands in promoters, is critical to carcinogenesis and metastasis. Here, we review the recent progress in the study of methylations of tumor suppressor genes involved in the pathogenesis of gastric cancer. We also briefly describe the mechanisms that induce tumor suppressor gene methylation and the status of translating these molecular mechanisms into clinical applications.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias Gástricas
/
Adesão Celular
/
Ciclo Celular
/
Genes Supressores de Tumor
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Regiões Promotoras Genéticas
/
Apoptose
/
Ilhas de CpG
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2013
Tipo de documento:
Artigo