Modification of novel oxazolidinone derivatives at C-5 side chain and their antibacterial activities / 药学学报

ABSTRACT

<p><b>AIM</b>To modify the C-5 side chains of the oxazolidinone derivatives and evaluate their in vitro antibacterial activities preliminarily.</p><p><b>METHODS</b>The title compounds were synthesized in 9 - 12 steps with the starting material 3-fluoroaniline and their in vitro antibacterial activities were examined by using Mueller-Hinton broth dilution method.</p><p><b>RESULTS</b>Thirty new compounds were designed and synthesized, in which eighteen novel title compounds were prepared and their structures were confirmed by 1H NMR and ESI-MS. Eleven compounds showed antibacterial activities to a certain extent, among them compounds 7a, 9a and 11a displayed promising activity.</p><p><b>CONCLUSION</b>Compounds 7a, 9a and 11a were worth further studying.</p>