Hepatic and renal injury induced by Radix Aristolochiae or Guanxin Suhe Wan for a long-term in rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1044-1048, 2008.
Article
em Zh
| WPRIM
| ID: wpr-295412
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the toxicity of Radix Aristolochiae supplied experimental evidence of rational use of drug in clinic.</p><p><b>METHOD</b>After treatment with small dose Radix Aristolochiae, Guanxin Suhe Wan (with Radix Aristolochiae) and Guanxin Suhe Wan (without Radix Aristolochiae) in different group for a long- term, respectively, the biochemical indicator of PT, ALT, AST, ALB, ALP, Crea and BUN were detected, and the kidney, liver, stomach and urinary bladder were examined by pathologic assaying.</p><p><b>RESULT</b>In Radix Aristolochiae group and Guanxin Suhe Wan (with Radix Aristolochiae) group, all of biochemical indicator were changed significantly, and hepatonecrosis, renal tubular necrosis, gastric carcinoma and bladder carcinoma were discovered.</p><p><b>CONCLUSION</b>Radix Aristolochiae and Guanxin Suhe Wan (with Radix Aristolochiae) can damage kidney and liver, and cause gastric carcinoma and bladder carcinoma by intensive toxicity.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Patologia
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Neoplasias Gástricas
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Bexiga Urinária
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Neoplasias da Bexiga Urinária
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Medicamentos de Ervas Chinesas
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Química
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Ratos Sprague-Dawley
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Aristolochia
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Toxicidade
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Rim
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Article