Progress in genetic and epigenetic research on in-stent restenosis after percutaneous coronary interventions / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 38-42, 2012.
Article
em Zh
| WPRIM
| ID: wpr-295537
Biblioteca responsável:
WPRO
ABSTRACT
Coronary heart disease is one of the most important causes of death in human, and consumes vast medical resources. Percutaneous coronary intervention (PCI) has been a significant breakthrough for its treatment. However, clinical application has been hampered by in-stent restenosis (ISR). Although drug eluting stent (DES) has reduced the occurrence of restenosis, incidence of ISR is still about 5% to 10%. The main reasons for restenosis after PCI are hyperplasia of vascular endothelial cells and smooth muscle cell migration. The exact mechanism of personalized differences in restenosis is not clear yet, but there may be a variety of risk factors. In addition to aging, smoking and diabetes, an increasing number of studies have found that genetic and epigenetic factors play an important role in ISR. In this article, authors have reviewed genetic and epigenetic factors on the progression of ISR, which may help to determine the genetic risk factors in patients with ISR after PCI.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Angioplastia Coronária com Balão
/
Stents
/
Resultado do Tratamento
/
Progressão da Doença
/
Reestenose Coronária
/
Epigenômica
/
Genética
/
Métodos
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2012
Tipo de documento:
Article