Expression of CD31, CD34 and CD105 in squamous cell carcinoma of tongue and their relationships with lymph node metastasis / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To research the expression of CD31, CD34 and CD105 in squamous cell carcinoma of tongue (TSCC) and discuss their relationships with lymph node metastasis.</p><p><b>METHODS</b>All the specimens' segments were stained by immunohistochemical method SP, and then the tumor's microvessel density (MVD) marked by CD31, CD34 and CD105 were counted by the Weidner's method.</p><p><b>RESULTS</b>The expression of CD31, CD34 and CD105 in the tumor's tissue was much higher than that in the normal tissue (P<0.01). There was no obvious difference between the MVD values marked by CD31 and CD34 (P>0.05), but they were obviously different from which marked by CD105 (P<0.01). The MVD values between the male and female patients had no statistical difference (P>0.05). The MVD values marked by CD31 and CD34 had no statistical difference in different pathological grades and clinical stages (P>0.05), but there was statistical difference in different pathological grades and clinical stages marked by CD105 (P<0.05). Although the MVD value of the cases with lymph node metastasis was different from that without metastasis marked by CD31 and CD34 (P<0.05), there was much higher difference between the cases with lymph node metastasis and those without metastasis marked by CD105 (P<0.01).</p><p><b>CONCLUSION</b>CD105 is a more satisfying vascular endothelial marker than others. It can predict the metastasis possibility of the TSCC patients, thus it may be particularly important in the development of TSCC.</p>