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Advances in targeted therapy for childhood acute myeloid leukemia / 中国当代儿科杂志
Article em Zh | WPRIM | ID: wpr-297199
Biblioteca responsável: WPRO
ABSTRACT
At present, acute myeloid leukemia (AML) accounts for about 15%-20% of childhood acute leukemia. Although overall survival rate is increasing with the help of risk stratification, stratification of chemotherapy, and supportive treatment, conventional pharmacotherapy still has a limited clinical effect and certain limitations in improving remission rate in previously untreated patients and reducing recurrence after remission. With the development of precision medicine, the mechanisms of targeted therapy, including abnormal activation of AML-related signaling pathways and epigenetic modification, have been found in recent years. Molecular-targeted drugs can therefore act on specific receptors and target genes to improve clinical effect and the prognosis of AML patients.
Assuntos
Texto completo: 1 Base de dados: WPRIM Assunto principal: Leucemia Mieloide Aguda / Mortalidade / Epigênese Genética / Tratamento Farmacológico / Terapia de Alvo Molecular / Imunoterapia Tipo de estudo: Prognostic_studies Limite: Child / Humans Idioma: Zh Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2017 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Leucemia Mieloide Aguda / Mortalidade / Epigênese Genética / Tratamento Farmacológico / Terapia de Alvo Molecular / Imunoterapia Tipo de estudo: Prognostic_studies Limite: Child / Humans Idioma: Zh Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2017 Tipo de documento: Article