Advances in targeted therapy for childhood acute myeloid leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 832-836, 2017.
Article
em Zh
| WPRIM
| ID: wpr-297199
Biblioteca responsável:
WPRO
ABSTRACT
At present, acute myeloid leukemia (AML) accounts for about 15%-20% of childhood acute leukemia. Although overall survival rate is increasing with the help of risk stratification, stratification of chemotherapy, and supportive treatment, conventional pharmacotherapy still has a limited clinical effect and certain limitations in improving remission rate in previously untreated patients and reducing recurrence after remission. With the development of precision medicine, the mechanisms of targeted therapy, including abnormal activation of AML-related signaling pathways and epigenetic modification, have been found in recent years. Molecular-targeted drugs can therefore act on specific receptors and target genes to improve clinical effect and the prognosis of AML patients.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Leucemia Mieloide Aguda
/
Mortalidade
/
Epigênese Genética
/
Tratamento Farmacológico
/
Terapia de Alvo Molecular
/
Imunoterapia
Tipo de estudo:
Prognostic_studies
Limite:
Child
/
Humans
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2017
Tipo de documento:
Article