Effects of methylene blue on refractory hemorrhagic shock / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 136-139, 2008.
Article
em Zh
| WPRIM
| ID: wpr-298727
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of methylene blue (MB) on refractory hemorrhagic shock.</p><p><b>METHODS</b>Totally 24 rabbits subjected to prolonged hemorrhagic shock and resuscitation were randomly divided into hemorrhagic shock group (12 rabbits) and MB group (12 rabbits; MB was administered immediately after resuscitation was performed). The plasma levels of tumor necrosis factor alpha (TNFalpha) , interleukin (IL)-6, IL-8, nitric oxide (NO), lactic acid (LA) , and mean arterial pressure (MAP) were detected before shock, immediately after resuscitation, and 0.5, 2, and 4 hours after resuscitation. The 12-hour survival rates were observed.</p><p><b>RESULTS</b>The plasma levels of TNFalpha, IL-6, IL-8, NO and LA after shock were significantly higher than before shock (P <0.01), and maintained at high levels. Compared with the shock group, higher MAP and lower plasma levels of TNFalpha, IL-6, IL-8, NO, and LA were observed in the MB group after resuscitation (P<0.01). The 12-hour survival rates were not significantly different between shock group and MB group.</p><p><b>CONCLUSION</b>Although MB can not improve the prognosis of refractory hemorrhagic shock, it can increase and maintain the MAP and thus play a beneficial role in the treatment of hemorrhagic shock.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Choque Hemorrágico
/
Sangue
/
Pressão Sanguínea
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Distribuição Aleatória
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Taxa de Sobrevida
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Mortalidade
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Interleucina-8
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Interleucina-6
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Fator de Necrose Tumoral alfa
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Ácido Láctico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2008
Tipo de documento:
Article