Prevalence of anti-endothelial cell antibodies in patients with pulmonary arterial hypertension associated with connective tissue diseases / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
; (4): 27-31, 2010.
Article
em En
| WPRIM
| ID: wpr-299464
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the prevalence of anti-endothelial cell antibodies (AECAs) in the sera of connective tissue diseases (CTD) patients with pulmonary arterial hypertension (PAH) and its correlation with clinical manifestations.</p><p><b>METHODS</b>AECAs in sera of 39 CTD patients with PAH, 22 CTD patients without PAH, and 10 healthy donors as controls were detected with Western blotting. The prevalence of different AECAs in different groups was compared and its correlation with clinical manifestations was also investigated.</p><p><b>RESULTS</b>The prevalence of AECAs was 82.1% in CTD patients with PAH, 72.7% in CTD patients without PAH, and 20.0% in healthy donors. Anti-22 kD AECA was only detected in CTD patients with PAH (15.4%). Anti-75 kD AECA was more frequently detected in CTD patients with PAH than in those without PAH (51.3% vs. 22.7%, P < 0.05). In CTD patients with PAH, anti-75 kD AECA was more frequently detected in those with Raynaud's phenomenon or with positive anti-RNP antibody.</p><p><b>CONCLUSION</b>AECAs could be frequently detected in CTD patients with or without PAH, while anti-22 kD and anti-75 kD AECA might be specific in CTD patients with PAH.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Autoanticorpos
/
Sangue
/
Linhagem Celular
/
Doenças do Tecido Conjuntivo
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Biologia Celular
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Células Endoteliais
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Alergia e Imunologia
/
Hipertensão Pulmonar
Tipo de estudo:
Prevalence_studies
Limite:
Adult
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Female
/
Humans
Idioma:
En
Revista:
Chinese Medical Sciences Journal
Ano de publicação:
2010
Tipo de documento:
Article