The relationship between expression of interleukin-8 and prognosis of breast cancer / 中华外科杂志
Chinese Journal of Surgery
; (12): 900-903, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-300590
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of interleukin-8 (IL-8) and its prognostic significance in breast cancer.</p><p><b>METHODS</b>Expression of IL-8 in 113 breast cancers, 19 breast benign tumors and 20 breast normal tissues was examined by tissue microarray using immunohistochemistry, and the association of IL-8 expression with patient's clinico-pathological characteristics and prognosis was further analyzed.</p><p><b>RESULTS</b>The positive rate of IL-8 expression in breast cancer was 27.4%, which was significantly higher than that in benign tumor and normal tissue of breast (P = 0.002). IL-8 expression related to histological type (P = 0.040) and lymph node status (P = 0.021). The expression of IL-8 was observed to correlate negatively with ER and PR status (P = 0.015 and P = 0.034), and correlate positively with C-erbB-2 status (P = 0.002). In addition, Kaplan-Meier curves of disease-free survival analysis showed a significant difference between IL-8 positive groups and negative group (P = 0.031).</p><p><b>CONCLUSIONS</b>IL-8 might be a poor prognostic factor for human breast cancer, and also might be a novel molecular marker to predicate the occurrence and progression of breast cancer.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Neoplasias da Mama
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Imuno-Histoquímica
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Receptores de Progesterona
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Receptores de Estrogênio
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Interleucina-8
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Receptor ErbB-2
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Diagnóstico
/
Metástase Linfática
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adulto
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Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2006
Tipo de documento:
Artigo