Pharmacokinetics of bromotetrandrin (W198) in rats and beagle dogs / 药学学报
Acta Pharmaceutica Sinica
; (12): 301-304, 2004.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-301090
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To study the pharmacokinetics of bromotetrandrine (W198) in rats and beagle dogs.</p><p><b>METHODS</b>The concentrations of W198 in serum were determined using HPLC method with UV detection.</p><p><b>RESULTS</b>The pharmacokinetic parameters of W198 after single iv doses of W198 10, 20 and 40 mg x kg(-1) in rats were as follows T1/2beta were 6.60, 7.36 and 6.77 h, AUC0-24 h were 3.797, 7.371 and 15.192 mg x h x L(-1), Vd were 7.14, 4.33 and 4.13 L x kg(-1), CL were 2.83, 2.60 and 2.71 L x (kg x h)(-1), respectively. The T1/2beta and AUCo-24 h of W198 after single im dose of W198 20 mg x kg(-1) in rats were 11.61 h and 12.646 mg x h x L(-1). The im bioavailability of W198 in rats was 56.9%. The T1/2beta, AUC0-24 h, Vd and CL of W198 after single iv dose of W198 5 mg x kg(-1) in beagle dogs were 11.72 h, 12.646 mg x h x L(-1), 0.70 L x kg(-1) and 0.46 L x (kg x h)(-1), respectively. The plasma protein binding ratio of W198 with human serum protein was 78.0%.</p><p><b>CONCLUSION</b>The absorption of W198 in rats was of first order kinetics.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ligação Proteica
/
Especificidade da Espécie
/
Medicamentos de Ervas Chinesas
/
Farmacocinética
/
Proteínas Sanguíneas
/
Disponibilidade Biológica
/
Ratos Wistar
/
Área Sob a Curva
/
Benzilisoquinolinas
/
Alcaloides
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2004
Tipo de documento:
Artigo