Synthesis of 1-indole substituted beta-carboline alkaloid and its derivatives and evaluation of their preliminary antitumor activities / 药学学报
Acta Pharmaceutica Sinica
; (12): 259-262, 2004.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-301101
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To synthesize eudistomin U and its 6-OCH3/Br derivatives and 5'-Br derivatives as antitumor agents.</p><p><b>METHODS</b>Using tryptamine and indole-3-aldehyde as starting materials, through condensation, Pictet-Spengler cyclization and dehydrogenation three steps, the alkaloids and its derivatives were prepared.</p><p><b>RESULTS</b>The structures of the compounds were determined by 1HNMR, MS and HRMS. Antitumor activity in vitro was tested.</p><p><b>CONCLUSION</b>Eudistomin U and its derivatives were synthesized. The results showed that they all showed antitumor activities against mouse P388 strain.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Carbolinas
/
Estrutura Molecular
/
Leucemia P388
/
Triptaminas
/
Divisão Celular
/
Química
/
Linhagem Celular Tumoral
/
Alcaloides
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2004
Tipo de documento:
Artigo