Expression of Integrin-а3 mRNA in Meningiomas and Its Correlation with Proliferation and Invasion / 华中科技大学学报（医学）（英德文版）

ABSTRACT

To investigate the expression of integdn-а3 mRNA in meningiomas and its correlation hybridization in patients with meningiomas (36 cases) and normal dura (2 cases) and arachnoid tis-sues (2 cases).SABC immunohistochemical assay was used to study the expression of Ki-67 nuclear antigen.The results showed that the expression of integdn-a3 mRNA in benign,atypical and malig-nant meningiomas was 2.52i-0.362,1.75±0.316 and 1.42±0.633,respectively.The expression levels invasive biological behavior was lower than that in those without invasion (I.63±0.462 vs.Ki-67 labeling index in all cases.It suggested that integrin-a3 subunit participated in the modulatory process of growth of meningiomas.The proliferation activity and malignant grade of meningiomas