Research progress on MAPK signal pathway in the pathogenesis of osteoarthritis / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 441-444, 2014.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-301797
Biblioteca responsável:
WPRO
ABSTRACT
Mitogen-activated protein kinases (MAPKs) signal is one of the important ways in eukaryotic cell,which adjusts and controls the structure and function of the cell. MAPKs in eukaryotes include p38, ERK, JNK and ERK5, etc. With the deepening research,we found that the activation of p38, ERK, JNK signal pathways were closely related with osteoarthritis (OA) cartilage injury. MAPKs are the key signaling systems involved in the production of matrix metalloproteinases and the regulation of cartilage cell proliferation, apoptosis and differentiation. Expecially the matrix metalloproteinases can accelerate the degradation of articular cartilage. So it has been the new spot in pathogenesis of osteoarthritis study.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoartrite
/
Patologia
/
Cartilagem Articular
/
Proteínas Quinases Ativadas por Mitógeno
/
Sistema de Sinalização das MAP Quinases
/
Metabolismo
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2014
Tipo de documento:
Artigo