Effect of arotinolol on left ventricular function in patients with idiopathic dilated cardiomyopathy / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
; (4): 224-227, 2007.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-302709
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of long-term treatment with arotinolol in patients with idiopathic dilated cardiomyopathy (IDCM).</p><p><b>METHODS</b>Sixty-three patients with IDCM were evaluated at baseline and after 12-month therapy with arotinolol. The conventional therapy for congestive heart failure was continued throughout the study with arotinolol as the only beta-blocker. Left ventricular function was assessed with the New York Heart Association functional class and two-dimensional echocardiography.</p><p><b>RESULTS</b>After 12-month arotinolol treatment, there was a significant improvement in left ventricular systolic function. Left ventricular end-systolic dimension significantly decreased from 59.52 +/- 8.83 mm to 50.89 +/- 8.17 mm (P < 0.001). Left ventricular ejection fraction significantly increased from 27.39% +/- 7.94% to 41.13% +/- 9.45% ( P < 0.001). Left ventricular mass index decreased from 150.47 +/- 42.42 g/m2 to 141.58 +/- 34.36 g/m2 (P < 0.01). No adverse events leading to premature discontinuation of study drug occurred.</p><p><b>CONCLUSION</b>In this preliminary study, 12-month arotinolol treatment has a favorable effect on left ventricular function in patients with IDCM, and it is safe and well tolerated.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Propanolaminas
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Ecocardiografia
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Cardiomiopatia Dilatada
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Função Ventricular Esquerda
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Antagonistas Adrenérgicos beta
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Usos Terapêuticos
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Tratamento Farmacológico
Limite:
Adulto
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Feminino
/
Humanos
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Masculino
Idioma:
Inglês
Revista:
Chinese Medical Sciences Journal
Ano de publicação:
2007
Tipo de documento:
Artigo