Synthesis and anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives / 药学学报

ABSTRACT

<p><b>AIM</b>To study the anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives.</p><p><b>METHODS</b>The target compounds were synthesized from p-nitroaniline via three steps and were evaluated for anti-inflammatory activity with the model of xylene-induced ear edema in mice.</p><p><b>RESULTS</b>Eleven compounds were obtained and confirmed by IR, 1HNMR and MS. Some compounds were shown to have significant anti-inflammatory activity.</p><p><b>CONCLUSION</b>N-(4-arylamidophenyl) methanesulfonamide showed appreciable anti-inflammatory activity.</p>