Elevated Plasma Pentraxin 3 and Its Association with Retinal Vein Occlusion
Korean Journal of Ophthalmology
; : 460-465, 2014.
Article
em En
| WPRIM
| ID: wpr-30317
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: To evaluate plasma pentraxin 3 (PTX3) in patients with retinal vein occlusion (RVO), and investigate the possibility of its role as a predictive biomarker. METHODS: Nested case-control study. The study included 57 patients with RVO and 45 age- and gender-matched subjects without RVO as controls. Plasma PTX3 and C-reactive protein concentration were measured in both groups a posteriori from frozen samples by using an enzyme-linked immunosorbent assay kit. RESULTS: The measured PTX3 value for the RVO group was 1,508 +/- 1,183 pg/mL (mean +/- standard deviation) and 833 +/- 422 pg/mL for the controls (p < 0.001). There was no significant difference in PTX3 levels between patients with central retinal vein occlusion and branched retinal vein occlusion (1,468 +/- 1,300 vs. 1,533 +/- 1,121 pg/mL; p = 0.818). CONCLUSIONS: Our data seems to support the role of chronic inflammation and ischemia in the development of RVO. It is possible that PTX3 can be used as a diagnostic biomarker of RVO.
Palavras-chave
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Oclusão da Veia Retiniana
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Proteína C-Reativa
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Proteínas de Fase Aguda
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Componente Amiloide P Sérico
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Ensaio de Imunoadsorção Enzimática
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Biomarcadores
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Estudos de Casos e Controles
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Korean Journal of Ophthalmology
Ano de publicação:
2014
Tipo de documento:
Article