Flavonoids of Echinps latifolius suppress Wnt signaling in adjuvant arthritis rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 129-133, 2015.
Article
em Zh
| WPRIM
| ID: wpr-305335
Biblioteca responsável:
WPRO
ABSTRACT
The role of flavonoids of Echinps latifolius (FELT) in Wnt signaling was investigated in adjuvant arthritis (AA) rats. The therapeutic effects of FELT on AA rats were detected by rat arthritis score and MTT. The effect of FELT gavage treatment on the Wnt signaling key gene β-catenin, C-myc and cyclin D1 in synovium from AA rats was detected by Real-time qPCR, and the effects of FELT gavage treatment on the upstream negative regulation gene SFRP 1,2,4,5 in synovium from AA rats were detected by Real-time qPCR. The results showed that FELT gavage treatment significantly inhibited arthritis score and MTT values in AA rats, significantly inhibited the expression of the Wnt signaling gene β-catenin, C-myc and cyclin D1, significantly up-regulated the expression of the up- stream negative regulation gene SFRP 1,2,4. FELT has a better therapeutic effect for AA rats.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Artrite Experimental
/
Membrana Sinovial
/
Flavonoides
/
Medicamentos de Ervas Chinesas
/
Transdução de Sinais
/
Regulação para Baixo
/
Química
/
Ratos Sprague-Dawley
/
Asteraceae
/
Peptídeos e Proteínas de Sinalização Intercelular
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Article