Experimental studies on treatment of HSV infections with photodynamic therapy using 5-aminolevulinic acid / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 79-82, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-305488
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate in vitro and in vivo anti-human herpes simplex virus effects of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA).</p><p><b>METHODS</b>Guinea pigs model of cutaneous herpes virus infection was applied, and Vero cells infected by HSV-I and HSV-II were used as experimental systems to observe the antiherpes effect of ALA-PDT.</p><p><b>RESULTS</b>The in vitro experiments showed that ALA-PDT has antiherpes effect on HSV-I and HSV-II, its effect was similar to that of acyclovir. The results of animal experiments showed that ALA-PDT had significant therapeutic effect on guinea pigs model of cutaneous herpes virus infection, the effect was dose-related.</p><p><b>CONCLUSION</b>ALA-PDT could be effective in treating HSV infections, which may provide a new approach to the treatment of viral infections.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fotoquimioterapia
/
Virologia
/
Células Vero
/
Distribuição Aleatória
/
Chlorocebus aethiops
/
Resultado do Tratamento
/
Dermatopatias Virais
/
Simplexvirus
/
Usos Terapêuticos
/
Modelos Animais de Doenças
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2007
Tipo de documento:
Artigo