Regulatory effect of GDNF on the proliferation and differentiation of mammalian spermatogonial stem cells / 中华男科学杂志
National Journal of Andrology
; (12): 628-633, 2011.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-305830
Biblioteca responsável:
WPRO
ABSTRACT
The glial cell-derived neurotrophic factor (GDNF) is a member of the transforming growth factor beta (Tgf-beta) superfamily, which is produced by Sertoli cells and plays an important role in the proliferation and differentiation of spermatogonial stem cells (SSC). The addition of proper amount of GDNF to the culture media can promote SSC proliferation in vitro. Besides, GDNF regulates the self-renewal and differentiation of SSCs through various signaling pathways. This review focuses on the effects of GDNF on the proliferation and differentiation of mammalian SSCs and GDNF-mediated signaling pathways.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espermatogônias
/
Células-Tronco
/
Transdução de Sinais
/
Diferenciação Celular
/
Biologia Celular
/
Proliferação de Células
/
Fator Neurotrófico Derivado de Linhagem de Célula Glial
/
Mamíferos
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2011
Tipo de documento:
Artigo