Phosphorylation and nuclear translocation of serine 722 and serine 910 of focal adhesion kinase in hypertrophic cardiac myocytes of left ventricle of spontaneously hypertensive rats / 中华病理学杂志
Chinese Journal of Pathology
; (12): 328-332, 2008.
Article
em Zh
| WPRIM
| ID: wpr-306020
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of focal adhesion kinase (FAK) in cardiac hypertrophy induced by hypertension.</p><p><b>METHODS</b>Using immunofluorescent labeling, confocal microscopy and Western blot, the expression and subcellular location of FAK-pSer722 and FAK-pSer910 were determined in cardiac myocytes of the left ventricles from 2, 6, 12, and 18 month-old spontaneously hypertensive heart failure (SHHF) rats and age-matched Wistar-Kyoto (WKY) control rats, respectively.</p><p><b>RESULTS</b>There was no obvious difference in FAK-pSer722 and FAK-pSer910 expression between 2 month-old SHHF and WKY rats. In contrast with the control groups, the expression of FAK-pSer722 and FAK-pSer910 significantly increased in cardiac myocytes of the left ventricle, from 6, 12 and 18 month-old SHHF rats. Both FAK-pSer722 and FAK-pSer910 were translocated and acummulated in nuclei of cardiac myocytes from 6, 12, and 18 month-old SHHF rats.</p><p><b>CONCLUSION</b>Phosphorylation and translocation of serine 722 and serine 910 of phosphorylated FAK play an important role in the de-compensatory cardiac hypertrophy.</p>
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Base de dados:
WPRIM
Assunto principal:
Patologia
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Fosforilação
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Fisiologia
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Ratos Endogâmicos SHR
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Ratos Endogâmicos WKY
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Serina
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Transdução de Sinais
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Núcleo Celular
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Cardiomegalia
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Transporte Proteico
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Pathology
Ano de publicação:
2008
Tipo de documento:
Article