Research on relationship of survivin gene expression with malignant proliferation and apoptosis of brain glioma / 中华外科杂志
Chinese Journal of Surgery
; (12): 885-888, 2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-306190
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression level of inhibitor of apoptosis protein survivin gene in human brain glioma and its role in malignant proliferation and antiapoptosis of brain glioma.</p><p><b>METHODS</b>Eighty-three cases of brain glioma specimen was chosen, protein expression of survivin and proliferating cell nuclear antigen (PCNA) was investigated by immunohistochemistry streptavidin-biotin complex (SABC) method, the immunoreactivity score (IRS) of survivin and the proliferative index (PI) were counted. Apoptotic cells were screened by TdT-mediated dUTP-biotin nick-end labeling (TUNEL) method, and the apoptotic index (AI) of brain glioma was calculated.</p><p><b>RESULTS</b>The survivin IRS, PI and AI of brain glioma were 3.8 +/- 3.9, (28.4 +/- 19.5)% and (1.0 +/- 0.8)% respectively, and all of them were elevated with the increase of pathological grade of brain glioma (P < 0.01 for all). PI in survivin positive group was significantly higher than that in survivin negative group (P < 0.01), and PI was positively correlated with survivin IRS (r = 0.740, P < 0.01). There was no significant difference between AI in survivin positive group and that in survivin negative group (P > 0.05), however, AI was negatively correlated with survivin IRS (r = -0.307, P < 0.01).</p><p><b>CONCLUSIONS</b>Survivin is overexpressed in brain glioma, and which may play important roles in malignant proliferation and antiapoptosis of brain glioma.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
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ODS3 - Meta 3.2 Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
Problema de saúde:
Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
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Neoplasias do Cérebro e Sistema Nervoso
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Cuidados de Saúde Neonatal
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Nutrição
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
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Neoplasias Encefálicas
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Imuno-Histoquímica
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Apoptose
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Antígeno Nuclear de Célula em Proliferação
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Marcação In Situ das Extremidades Cortadas
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Proliferação de Células
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Proteínas Inibidoras de Apoptose
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Genética
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Glioma
Limite:
Adolescente
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Adulto
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Idoso
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Criança
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Criança, pré-escolar
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Feminino
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Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2005
Tipo de documento:
Artigo