Advance of the study on LRRK2 gene in Parkinson's disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 657-659, 2008.
Article
em Zh
| WPRIM
| ID: wpr-307998
Biblioteca responsável:
WPRO
ABSTRACT
The leucine-rich repeat kinase2 (LRRK2) has been identified to be the gene causing autosomal dominant inherited Parkinson's disease(PD)8. The clinical features of this type of PD are similar to those of idiopathic PD, but the pathological changes are diverse. The mutation types and frequencies of the LRRK2 distribute unevenly in different populations. LRRK2 is a large complex protein with multiple functions and expresses widely in human body. Sequence alignment shows that LRRK2 might be a multiple function kinase for substrate phosphorylation and might also act as a scaffolding protein. Further study on the physiological function and pathogenic mechanism of LRRK2 will help to find out the possible pathogenesis and new treatment for PD.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Doença de Parkinson
/
Patologia
/
Química
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Alinhamento de Sequência
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Proteínas Serina-Treonina Quinases
/
Grupos Raciais
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Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina
/
Genética
/
Metabolismo
/
Mutação
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2008
Tipo de documento:
Article