Chemotherapy in conjunction with traditional Chinese medicine for survival of elderly patients with advanced non-small-cell lung cancer: protocol for a randomized double-blind controlled trial / 中西医结合学报
Journal of Integrative Medicine
; (12): 175-181, 2014.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-308199
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Traditional Chinese medicine (TCM) is considered an important complementary therapy with beneficial effects for cancer patients. Elderly patients with non-small-cell lung cancer (NSCLC) are a complex patient group with increasing co-morbidity and shrinking physiological reserve, and may derive substantial benefit from the supportive aspects of TCM. Researchers from Shanghai Longhua Hospital found that qi and yin deficiency is a common syndrome in patients with stage III or IV lung cancer. This project was designed to study the combination of single-agent chemotherapy with TCM methods of benefiting qi and yin in elderly patients with advanced NSCLC.</p><p><b>METHODS AND DESIGN</b>This is a double-blind controlled, multi-center, and prospective study with randomly selected participants from elderly NSCLC patients in China. Seventy-six patients who meet the inclusion criteria will be allocated into two groups, which will receive treatments of 3-week single-agent chemotherapy with TCM or placebo for four cycles. Progression-free survival (PFS) is the primary end point, and the secondary end points are overall survival, objective response rate, time-to-progression, and quality of life (EORTC QLQ-LC43, and TCM syndrome score). Meanwhile, other end points such as toxicity, side effects and safety of the treatments will be assessed.</p><p><b>DISCUSSION</b>Results from this study may provide evidence on the effectiveness, and parameters for the usage of single-agent chemotherapy combined with or without TCM on PFS of elderly patients with NSCLC.</p><p><b>TRIAL REGISTRATION</b>ClinicalTrials.gov. (Identifier NCT01780181).</p>
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
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ODS3 - Saúde e Bem-Estar
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ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
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Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
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Outras Doenças Respiratórias
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Doença dos Órgãos dos Sentidos
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Neoplasias do Pulmão, Traqueia e Brônquios
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Método Duplo-Cego
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Estudos Prospectivos
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Mortalidade
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Terapia Combinada
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Carcinoma Pulmonar de Células não Pequenas
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Intervalo Livre de Doença
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Tratamento Farmacológico
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Neoplasias Pulmonares
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Medicina Tradicional Chinesa
Tipo de estudo:
Ensaio clínico controlado
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Estudo diagnóstico
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Estudo observacional
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Estudo prognóstico
Aspecto:
Preferência do paciente
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Journal of Integrative Medicine
Ano de publicação:
2014
Tipo de documento:
Artigo