Early diagnosis of prostate cancer using free/total prostate-specific antigen ratio with population-based screening data / 中华男科学杂志
National Journal of Andrology
; (12): 582-585, 2004.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-308296
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the use of free/total prostate-specific antigen ratio (fPSA/tPSA ratio) in improving the early diagnosis of prostate cancer.</p><p><b>METHODS</b>fPSA/tPSA ratio in the serum was analyzed prospectively in 187 men with tPSA ranging between 4.0 and 20.0 microg/L. All of them underwent ultrasound-guided sextant prostatic biopsies. Sensitivity, specificity, positive and negative predictive values were calculated by SPSS 10.0 software.</p><p><b>RESULTS</b>Prostate cancer detection rates were 18.1% and 22.5% when tPSA was within the ranges of 4.0-10.0 g/L and 10.0-20.0 g/L respectively. fPSA/tPSA ratio was more significant than tPSA in all the men. When the cut-off value of fPSA/tPSA ratio was set at 0.25, 90.5% and 87.5% of cancers could be detected; and 26.7% and 11.3% of biopsies could be avoided within the tPSA ranges of 4.0-10.0 g/L and 10.0-20.0 g/L, respectively.</p><p><b>CONCLUSION</b>The use of fPSA/tPSA ratio can improve prostate cancer detection and reduce unnecessary biopsies when tPSA is within the range of 4.0-10.0 microg/L and 10.0-20.0 microg/L.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
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Neoplasia da Próstata
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias da Próstata
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Sangue
/
Programas de Rastreamento
/
Estudos Prospectivos
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Sensibilidade e Especificidade
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Antígeno Prostático Específico
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Área Sob a Curva
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Diagnóstico Precoce
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
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Estudo de rastreamento
Limite:
Idoso
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Idoso, 80 anos ou mais
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Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2004
Tipo de documento:
Artigo