NADPH oxidase: recent evidence for its role in erectile dysfunction / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 6-13, 2008.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-310438
Biblioteca responsável:
WPRO
ABSTRACT
Important roles for reactive oxygen species (ROS) in physiology and pathophysiology have been increasingly recognized. Under normal conditions, ROS serve as signaling molecules in the regulation of cellular functions. However, enhanced ROS production as a result of the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contributes significantly to the pathogeneses of vascular diseases. Although it has become evident that increased ROS is associated with erectile dysfunction (ED), the sources of ROS in the penis remain largely unknown. In recent years, emergent evidence suggests the possible role of NADPH oxidase in inducing ED. In this review, we examine the relationship between ROS and ED in different disease models and discuss the current evidence basis for NADPH oxidase-derived ROS in ED.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Envelhecimento
/
Espécies Reativas de Oxigênio
/
NADPH Oxidases
/
Hiper-Homocisteinemia
/
Diabetes Mellitus
/
Hiperlipidemias
/
Hipertensão
/
Disfunção Erétil
Aspecto:
Pesquisa de implementação
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2008
Tipo de documento:
Artigo