AZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 674-678, 2007.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-310467
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To evaluate for the first time the frequency of Y chromosome microdeletions and the occurrence of the partial deletions of AZFc region in Moroccan men, and to discuss the clinical significance of AZF deletions.</p><p><b>METHODS</b>We screened Y chromosome microdeletions and partial deletions of the AZFc region of a consecutive group of infertile men (n = 149) and controls (100 fertile men, 76 normospermic men). AZFa, AZFb, AZFc and partial deletions of the AZFc region were analyzed by polymerase chain reaction (PCR) according to established protocols.</p><p><b>RESULTS</b>Among the 127 infertile men screened for microdeletion, four subjects were found to have microdeletions two AZFc deletions and two AZFb+AZFc deletions. All the deletions were found only in azoospermic subjects (4/48, 8.33%). The overall AZFc deletion frequency was low (4/127, 3.15%). AZF microdeletions were not observed in either oligoasthenoteratozoospermia (OATS) or the control. Partial deletions of AZFc (gr/gr) were observed in a total of 7 of the 149 infertile men (4.70%) and 7 partial AZFc deletions (gr/gr) were found in the control group (7/176, 3.98%). In addition, two b2/b3 deletions were identified in two azoospermic subjects (2/149, 1.34%) but not in the control group.</p><p><b>CONCLUSION</b>Our results suggest that the frequency of Y chromosome AZF microdeletions is elevated in individuals with severe spermatogenic failure and that gr/gr deletions are not associated with spermatogenic failure.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Valores de Referência
/
Espermatogênese
/
Diagnóstico por Imagem
/
Ultrassonografia
/
Deleção de Sequência
/
Proteínas de Plasma Seminal
/
Cromossomos Humanos Y
/
Loci Gênicos
/
Fertilidade
/
Genética
Tipo de estudo:
Estudo diagnóstico
/
Guia de prática clínica
Limite:
Humanos
/
Masculino
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2007
Tipo de documento:
Artigo