Association between genetic polymorphism in xeroderma pigmentosum G gene and risks of laryngeal and hypopharyngeal carcinomas / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 703-706, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-313702
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between polymorphism of DNA repair gene xeroderma pigmentosum G (XPG) Asp1104His and the risks of developing laryngeal and hypopharyngeal carcinomas.</p><p><b>METHODS</b>Totally 175 patients with laryngeal or hypopharyngeal carcinoma and 525 cancer-free controls were genotyped for the polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The odds ratio (OR) and 95% confidence interval (CI) were calculated using unconditional logistic regression model.</p><p><b>RESULTS</b>Compared with those having the Asp/Asp genotype, patients having the XPG 1104Asp/His genotype had a higher risk for laryngeal carcinoma (OR = 2.46, 95% CI = 1.15-5.24, P < 0.05), but not for hypopharyngeal carcinoma (OR = 1.36, 95% CI = 0.87-2.12, P > 0.05). In addition, the XPG 1104Asp/His genotype appeared to be associated with well differentiated squamous cell carcinoma in both larynx and hypopharynx (OR = 1.88, 95% CI = 1.05-3.40, P < 0.05 ).</p><p><b>CONCLUSION</b>The XPG Asp1104His polymorphism may play a role in the development of laryngeal and hypopharyngeal carcinomas.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Polimorfismo Genético
/
Neoplasias Hipofaríngeas
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Estudos de Casos e Controles
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Neoplasias Laríngeas
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Predisposição Genética para Doença
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Proteína Grupo D do Xeroderma Pigmentoso
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Genética
/
Genótipo
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2006
Tipo de documento:
Artigo