Immune regulation role of A20 and its clinical significance / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 851-856, 2011.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-313879
Biblioteca responsável:
WPRO
ABSTRACT
A20 was originally identified as a TNFα-induced protein 3 (TNFAIP3), a key regulator of inflammation signalling pathways, as well as a NF-κB inhibitor. It plays a critical role in regulation of innate and adoptive immunity. Recently, A20 has also been proposed to function as a tumor suppressor. Lacking A20 gene is involved in inflammation-mediated autoimmune disease and tumorigenesis in several human B-cell lymphomas. Current advance concerning the feature of A20 expression in immune cells, the biological function, the immune regulated function in native immunity, humoral and cellular immunity, the inactivation of A20 in lymphocytic malignancies and the polymorphism and abnormal expression of A20 in autoimmune disease indicate that the clinical significance of A20 should be worthy to recognize and to be further employed in induction of immune tolerance, antitumor immuno-regulated therapy and antiviral immunotherapy and so on.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Autoimunes
/
Proteínas Nucleares
/
Genes Supressores de Tumor
/
NF-kappa B
/
Fator de Necrose Tumoral alfa
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Proteínas de Ligação a DNA
/
Alergia e Imunologia
/
Imunidade Adaptativa
/
Proteína 3 Induzida por Fator de Necrose Tumoral alfa
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2011
Tipo de documento:
Artigo