Effect of extract of Ginkgo biloba on doxorubicin-associated cardiotoxicity in patients with breast cancer / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 68-70, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-315178
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of extract of Ginkgo biloba (Egb761) on doxorubicin-associated cardiotoxicity in patients with breast cancer (BC).</p><p><b>METHODS</b>Sixty BC patients in stage IV were randomly assigned to two groups, the control group was treated with chemotherapy, using 4 cycles of PA protocol alone and the treated group with the same chemotherapy and Egb761. Changes in electrocardiogram (ECG), myocardial enzyme spectrum (MES) and ultrasono-cardiogram (USCG) before and after treatment were observed.</p><p><b>RESULTS</b>After treatment, the incidence of abnormal ECG was lower in the treated group than in the control group (6.7% vs 30.0%); significant differences were found between the two groups in the parameters of MES (P< 0.05); USCG showed significant difference between the two groups in left ventricular diastolic diameter (LVDd), left ventricular systolic diameter (LVDs), ratio of early and late diastolic transmitral peak flow velocity (E/A) and fractional shortening (FS), while there was no significant difference in ejection fraction (EF).</p><p><b>CONCLUSION</b>Egb761 is an ideal drug for preventing and reducing the acute doxorbincin-induced cardiotoxicity; it could also be helpful for alleviating the chronic cardiotoxicity.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias da Mama
/
Extratos Vegetais
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Doxorrubicina
/
Química
/
Resultado do Tratamento
/
Carcinoma Ductal de Mama
/
Disfunção Ventricular Esquerda
/
Ginkgo biloba
/
Usos Terapêuticos
Tipo de estudo:
Guia de prática clínica
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2008
Tipo de documento:
Artigo