Clinical studies on apexification with demineralized dentin matrix / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the clinical effects of demineralized dentin matrix (DDM) as a apexificating agent.</p><p><b>METHODS</b>Human teeth were crushed into fragments and were deflated, demineralized, lyophilized to produce DDM. The DDM was used as an apexificating agent to treat 57 teeth compared with calcium hydroxide. X-ray film and clinical observation were undertaken after half a year, one year and two years.</p><p><b>RESULTS</b>One year later, a barrier in the tooth apex was found in the X-rays film. Then permanent filling material was used. After two years, DDM group had a healing rate of 92.86%, was higher than that of 91.30% in calcium hydroxide group, but there were no statistical significance.</p><p><b>CONCLUSION</b>The findings suggest that DDM can be used as a new apexificating agent. One year after the apexification is the best opportunity to change the apexificating agent to a permanent root canal filling material.</p>