A novel class of testis-specific small RNAs: piRNAs / 中华男科学杂志
National Journal of Andrology
; (12): 163-165, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-319271
Biblioteca responsável:
WPRO
ABSTRACT
Eukaryotes produce various types of 19-30 nt small RNAs, which act as guides to the regulation of gene expressions, such as mRNA degradation and translational repression. The Argonaute family members related to small RNA functions fall into 2 subfamilies. One is the AGO subfamily, whose 4 members distribute widely, confirmedly bind to miRNAs and siRNAs and inhibit the expression of target mRNAs through a pathway like RNA interference. The other is the PIWI subfamily, including PIWI, Aubgine (AUB) and AGO3, exclusively expressed in the testis. Recently, four research groups have isolated a new class of small RNAs from the mammalian testis, which interacts with the PIWI subfamily, hence named piwi-interfering RNAs (piRNAs), and is suggestive of an important role in spermatogenesis.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espermatogênese
/
Testículo
/
Classificação
/
MicroRNAs
/
RNA Interferente Pequeno
/
Interferência de RNA
/
Genética
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2008
Tipo de documento:
Artigo