Insulin resistance model induced by dexamethasone in rats / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To build a easy and reliable rat model of insulin resistance.</p><p><b>METHODS</b>Changes concerning sugar metabolism were observed in experimental rats injected intraperitoneally by different doses of dexamethasone.</p><p><b>RESULTS</b>The changes by dexamethasone in fasting blood insulin and insulin resistance prior to that of fasting blood glucose were dose and time dependent.</p><p><b>CONCLUSION</b>It was convenience to set up a insulin resistance model induced by dexamethasone in rats which would favor other related research.</p>