Expression of calponin in periglomerular myofibroblasts of rat kidney with experimental chronic injuries / 대한해부학회지
Anatomy & Cell Biology
; : 132-139, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-31960
Biblioteca responsável:
WPRO
ABSTRACT
Our previous research demonstrated that calponin-immunoreactivity was localized in myofibroblasts of the periglomerular region of human kidney specimens obtained at the time of transplantation from organ recipients. In the present study we examined calponin expression in two chronic nephropathy models, puromycin aminonucleoside (PAN) nephropathy and subtotal nephrectomy (SNx), to investigate the role of calponin in chronic renal injury. Male Sprague-Dawley rats were used, and both nephropathy models were established at 1, 2, 4, and 8 weeks after surgery. There were no periglomerular calponin-positive cells in sham, PAN 1 and 2 week, and SNx 1, 2, and 4 week groups. In SNx 8 week and PAN 4 and 8 week groups, only a few glomeruli with periglomerular calponin-reactivity, which covered half or a very small part of the periglomerular space, were observed. All glomeruli with periglomerular calponin-reactivity showed sclerotic changes, especially thickening of parietal epithelial cells (PECs). In conjunction with our previous report, this data represents the first documentation of the expression of calponin in renal myofibroblasts. We suggest that interactions between PECs and calponin-positive myofibroblasts may play a key role in the late stage of glomerulosclerosis.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas de Ligação ao Cálcio
/
Imuno-Histoquímica
/
Puromicina Aminonucleosídeo
/
Salicilamidas
/
Ratos Sprague-Dawley
/
Transplantes
/
Células Epiteliais
/
Miofibroblastos
/
Rim
/
Falência Renal Crônica
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Anatomy & Cell Biology
Ano de publicação:
2010
Tipo de documento:
Artigo