Expression of B7-H4 in prostate cancer and its clinical significance / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression of B7-H4 in prostate cancer tissue and the relationship between the expression and the clinicopathological features.</p><p><b>METHODS</b>Immunohistochemical staining was used to detect the expression of B7-H4 in prostate cancer tissue. And the relationship between the expressions and pathology was evaluated.</p><p><b>RESULTS</b>The B7-H4 was diffusely expressed in cytoplasm and/or membrane of the prostate cancer tissue; the expression was much higher than that in normal prostate tissue (P<0.05). The expression of B7-H4 in the prostate cancer tissue was higher in patients with higher tumor grade.</p><p><b>CONCLUSION</b>B7-H4 may be used as an new indicator for the diagnosis and prognosis of prostate cancer and a novel target for immunotherapy.</p>