Establishment of occupational exposure limit for warfarin in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 513-516, 2013.
Article
em En
| WPRIM
| ID: wpr-320309
Biblioteca responsável:
WPRO
ABSTRACT
This study aims to establish the occupational exposure limit (OEL) in the air for workplace of warfarin based on the available toxicological studies and field investigations by using questionnaire and air monitoring. The clinical therapeutic dose was used as lowest observed effect level (LOEL), and no observed effect level (NOEL) was achieved by using a safety factor. The highest concentration of warfarin monitored in the worksite of centrifuge washing, drying and packing were 0.029 mg/m3, 0.051 mg/m3 respectively, which did not exceed the OEL 0.1 mg/m3 recommended by NIOSH and ACGIH. Considering its feasibility for enforcement and protection for workers, we recommend OEL 0.1 mg/m3 of warfarin in China.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Padrões de Referência
/
Varfarina
/
China
/
Fatores de Risco
/
Exposição Ocupacional
/
Toxicidade
/
Anticoagulantes
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2013
Tipo de documento:
Article