Clustering of inflammatory biomarkers and risk of hypertension in a Mongolian population in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 562-568, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-320398
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>There is little knowledge on whether there is clustering of inflammatory biomarkers, such as C-reactive protein (CRP), soluble intracellular adhesion molecule1-1 (sICAM-1), and angiotensin II (Ang II), in individuals with hypertension in the Mongolian population. In the present study, we investigated this relationship in a Mongolian population in China.</p><p><b>METHODS</b>A total of 2589 adult Mongolians, aged 20 years and older, were recruited as study participants. Data on demographics, lifestyle, family history of hypertension, blood pressure, and blood chemistry were collected, and inflammatory biomarkers were measured in all participants.</p><p><b>RESULTS</b>The proportion of subjects with increased levels of two or three biomarkers was significantly higher in those with hypertension (21.0% and 6.0%, respectively) than in those with prehypertension (12.7% and 0.5%, respectively) or normotension (8.1% and 0.2%, respectively). The multivariate adjusted odds ratios (95% confidence interval) of hypertension associated with increased levels of one, two or three biomarkers were 0.94 (0.72-1.22), 1.42 (0.93-2.16), and 11.08 (1.45-84.80), respectively, compared with subjects with no increase in any biomarker.</p><p><b>CONCLUSION</b>Hypertension was associated with a cluster of inflammatory biomarkers in the Mongolian population.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteína C-Reativa
/
Angiotensina II
/
Marcadores Genéticos
/
China
/
Molécula 1 de Adesão Intercelular
/
Predisposição Genética para Doença
/
Povo Asiático
/
Genética
/
Hipertensão
/
Inflamação
Tipo de estudo:
Estudo de etiologia
Limite:
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2012
Tipo de documento:
Artigo