A preliminary study of anti-aging and wound healing of recombination cytoglobin / 药学学报
Acta Pharmaceutica Sinica
; (12): 51-57, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-323081
Biblioteca responsável:
WPRO
ABSTRACT
In this paper, the preliminary study on antioxidant, enhancement of antioxidant enzymes activity, reducing the content of oxygen free radicals, delaying skin aging of the recombination cytoglobin (rCygb) purified by our lab were investigated through human keratinocyte cell line (HaCAT) H2O2 oxidative stress model, mouse skin aging model caused by continuous subcutaneous injection D-gal, rat acute liver injury model induced by CCl4 and rat skin wound healing model. The results showed that rCygb improved the activities of total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT), reduced the activities of lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) as well as decreased the content of malondialdehyde (MDA). Skin biopsy showed that rCygb promoted angiogenesis, increased expression of collagen and improved the anti-inflammatory ability. All results displayed that rCygb improved the oxygen free radical scavenging ability, delayed skin aging and promoted wound healing.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Superóxido Dismutase
/
Cicatrização
/
Proteínas Recombinantes
/
Envelhecimento
/
Globinas
/
Tetracloreto de Carbono
/
Catalase
/
Distribuição Aleatória
/
Queratinócitos
Tipo de estudo:
Ensaio clínico controlado
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo