Expression and its relationship of PRL-3 and RhoC in non-small cell lung cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 598-601, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-323821
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>BACKGROUND AND OBJECTIVE</b>Phosphatase of regenerating liver-3 (PRL-3) is a newly identified protein-tyrosine phosphatase, which belongs to phosphatase of regenerating liver family, and plays a role in promoting tumor metastasis; Ras homologue C (RhoC) belongs to Rho subfamily of small-molecule G protein superfamily. However, the mechanisms of PRL-3 and RhoC are unknown. The aim of this study is to investigate the expressions of PRL-3 and RhoC proteins and their correlation to invasion and metastasis of non-small cell lung cancer (NSCLC), which may provide experiment evidence of the mechanism of PRL-3 in tumorigenesis and tumor-development.</p><p><b>METHODS</b>Immunohistochemical staining was used to detect the expressions of PRL-3 and RhoC in NSCLC in 92 cases, and statistical methods were used to analyse statistical significances of their expressions in different groups and their correlation.</p><p><b>RESULTS</b>The positive rates of PRL-3 and RhoC expressions in NSCLC were 69.6% (64/92) and 73.9% (68/92), respectively, and the expressions of PRL-3 and RhoC were closely correlated with TNM stage and lymphatic metastasis and pleural metastasis (P < 0.01), and they were correlated with each other (r = 0.754, P < 0.001).</p><p><b>CONCLUSION</b>The expressions of PRL-3 and RhoC are higher in the higher TNM stage and lymphatic metastasis and pleural metastasis cases, and closely correlate with each other in NSCLC, which suggests that PRL-3 and RhoC might be in the same signal pathway and PRL-3 might promote the distant metastasis of cancer cell by RhoC and downstream factors.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
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Imuno-Histoquímica
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Química
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Proteínas Tirosina Fosfatases
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Carcinoma Pulmonar de Células não Pequenas
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Proteínas rho de Ligação ao GTP
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Proteína de Ligação a GTP rhoC
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Genética
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Neoplasias Pulmonares
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
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Idoso
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Feminino
/
Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Lung Cancer
Ano de publicação:
2010
Tipo de documento:
Artigo