Studies on separation, appraisal and the biological activity of 5-HMF in Cornus officinalis / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 392-484, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-324275
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To develop the mechanism of improving protection function of prepared Cornus officinalis for liver and kidney and the biological activity of 5-hydroxymethylfurfural (5-HMF).</p><p><b>METHOD</b>Pharmacological and chemical studies were used to choose active part. A compound from active part was separated and appraised. To investigate his biological functions, pharmacological experiment was actualized.</p><p><b>RESULT</b>A component was separated and identified. His is 5-HMF. 5-HMF can protect human vein epidermal cell against H2O2 and glucose and inprove acute liver injury in mice.</p><p><b>CONCLUSION</b>5-HMF is the active component in prepared Cornus officinalis and substance basis for protecting liver and kidney.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Distribuição Aleatória
/
Células Cultivadas
/
Química
/
Cornus
/
Células Endoteliais
/
Furaldeído
/
Fígado
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo