Clinical observation of serum IL-18, IL-10 and sIL-2R levels in patients with chronic hepatitis C pre- and post antiviral treatment / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 605-608, 2003.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-324381
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the roles of serum interleukin-18 (IL-18), interleukin-10 (IL-10) and soluble interleukin-2R (sIL-2R) in the pathogenesis of chronic hepatitis C and to observe the effects of interferon (IFN) on the above- mentioned serum cytokines.</p><p><b>METHODS</b>The levels of above- mentioned cytokines were detected in 10 healthy individuals, 24 asymptomatic hepatitis virus C (HCV) carriers and 27 patients with chronic hepatitis C (before and after IFN treatment) using enzyme linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>The levels of the cytokines in patients with chronic hepatitis C are higher than in healthy people (P < 0.05) and in asymptomatic HCV carriers (P < 0.05). The values of the cytokines show a significant positive correlation to ALT (P < 0.05). Levels of tested cytokines decreased observably after IFN treatment (P < 0.05). The grades of the serum levels for sIL-2R and IL-10 before IFN treatment (from high to low) were categorized accordingly non-response group > partial- response group > complete- response group (P < 0.05).</p><p><b>CONCLUSIONS</b>The tested cytokines co-participate in the pathogenesis of chronic hepatitis C, and can be used to evaluate the effect of IFN on the immune state of organisms. Furthermore, sIL-2R and IL-10 are important for predicting the anti-viral efficacy of IFN.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Sangue
/
Proteínas Recombinantes
/
Receptores de Interleucina-2
/
Interleucina-10
/
Interferon-alfa
/
Hepatite C Crônica
/
Interleucina-18
/
Usos Terapêuticos
/
Tratamento Farmacológico
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2003
Tipo de documento:
Artigo