Efffect of addition of low-dose rosiglitazone to sulphonylurea therapy on glycemic control in type 2 diabetic patients / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 785-787, 2003.
Article
em En
| WPRIM
| ID: wpr-324411
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>We designed a multi-center, double-blind, randomized, parallel, with metformin controlled clinical trial to evaluate the efficacy and safety of low dose rosiglitazone combined with sulphonylurea therapy in type 2 diabetic patients who were inadequately controlled with sulphonylurea alone.</p><p><b>METHODS</b>Patients were treated with 4 mg rosiglitazone once daily plus sulphonylurea (test group) or 0.5 g metformin twice daily plus sulphonylurea (control group) for 12 weeks. The mean levels of HbA(1c), fasting and postprandial plasma glucose were recorded and compared between the two groups.</p><p><b>RESULTS</b>The mean levels of HbA(1c) decreased by 1.09% and 0.95% in the test group (n = 102) and control group (n = 96) respectively. Fasting and postprandial plasma glucose levels in the test group decreased by 25.0% and 35.6%, and in the control group, decreased by 17.7% and 23.8% as compared with the baseline (both P < 0.01). No liver damage was found.</p><p><b>CONCLUSION</b>Combination treatment of rosiglitazone and sulphonylurea can effectively improve glycemic control in type 2 diabetic patients inadequately controlled with sulphonylurea alone.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Compostos de Sulfonilureia
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Tiazóis
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Glicemia
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Método Duplo-Cego
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Tiazolidinedionas
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Diabetes Mellitus Tipo 2
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Tratamento Farmacológico
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Quimioterapia Combinada
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Hipoglicemiantes
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Metformina
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged
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Humans
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2003
Tipo de documento:
Article