The potential role of IGF-I receptor mRNA in rats with diabetic retinopathy / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 478-480, 2003.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-324445
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the potential role of insulin-like growth factor-1 receptor mRNA (IGF-IR mRNA) in the onset and development of retinopathy in diabetic rats.</p><p><b>METHODS</b>A diabetic model was duplicated in Wistar rats. The early changes in the retina were examined using light and transmission electron microscopy. Expression of IGF-IR mRNA was analyzed using in situ hybridization.</p><p><b>RESULTS</b>Weak expression of IGF-IR mRNA (5%) was found in retinas of normal rats, but was significantly increased (15% and 18%) in the retinas of diabetic rats after 3 and 6 months of diabetes (P < 0.01). In situ hybridization and morphological study demonstrated that there was a positive correlation between IGF-IR mRNA expression and retinal changes at various stages.</p><p><b>CONCLUSION</b>Increased IGF-IR mRNA might play an important role in the onset and development of diabetic retinopathy.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
/
Retina
/
Glicemia
/
Hemoglobinas Glicadas
/
RNA Mensageiro
/
Fator de Crescimento Insulin-Like I
/
Receptor IGF Tipo 1
/
Ratos Wistar
/
Retinopatia Diabética
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2003
Tipo de documento:
Artigo