Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression / 南方医科大学学报
Journal of Southern Medical University
; (12): 2442-2445, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-325095
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the presence of abnormal metabolism in the thalamus and hypothalamus in patients with first-episode depression.</p><p><b>METHODS</b>Thirty drug-naive patients with first-episode depression and 30 age-matched controls were scanned with proton magnetic resonance spectroscopy ((1)H-MRS) for Naa, Cho, Cr and mI.</p><p><b>RESULTS</b>Compared with the control group, the patients showed significantly reduced mI and mI/Cr of the hypothalamus, reduced mI/Cr of the left thalamus, and lowered Cho, ml, and ml/Cr of the right thalamus (P<0.05).</p><p><b>CONCLUSION</b>Patients with first-episode depression may have myo-inositol and phosphoric acid metabolism disorder in the thalamus and hypothalamus with malfunction of cellular osmotic pressure adjustment mechanism. Abnormal mI/Cr in the thalamus and hypothalamus may represent an important biochemical change in advanced patients with depression.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Saúde Mental e Transtornos do Comportamento
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prótons
/
Tálamo
/
Espectroscopia de Ressonância Magnética
/
Estudos de Casos e Controles
/
Colina
/
Creatina
/
Depressão
/
Diagnóstico
/
Hipotálamo
/
Inositol
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Artigo