Analysis of fetal chromosomal karyotype and etiology in 252 cases of early spontaneous abortion / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 575-578, 2011.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-326887
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between fetal chromosomal karyotype and early spontaneous abortion, and the effect of the environmental factors on spontaneous abortion.</p><p><b>METHODS</b>Choronic villi from 252 cases of missed abortion were sampled as patient group and 50 normal pregnancies as control group. Chorionic villi were cultured and karyotype analysis was performed by G-banding. Clinical information was collected.</p><p><b>RESULTS</b>The rate of chorion chromosome abnormality in the patient group was 58.09%, significantly higher than that in the control group (4.17%) (P<0.01). Among the 140 cases of karyotype abnormalities, 81 were trisomy, 29 were monosomy X and 17 were polyploidy, accounting for 57.86%, 20.71% and 12.14% of total abnormalities, respectively. Long time and low dose radiation exposure of the pregnant female seemed to be related with spontaneous abortion(P<0.01).</p><p><b>CONCLUSION</b>Chorion chromosome abnormality is a major reason of early spontaneous abortion and karyotype analysis of chorionic villus is of clinical importance. For pregnant women, long-term exposure to computers and television seems a risk factor for missed abortion.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estudos de Casos e Controles
/
Fatores de Risco
/
Vilosidades Coriônicas
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Aberrações Cromossômicas
/
Aborto Retido
/
Genética
/
Cariotipagem
/
Metabolismo
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
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Fatores de risco
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Gravidez
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2011
Tipo de documento:
Artigo