Cytogenetic study of mantle cell lymphoma / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 283-286, 2011.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-326946
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the cytogenetic features of mantle cell lymphoma (MCL).</p><p><b>METHODS</b>Bone marrow cells from 18 MCL patients with bone marrow invasion were cultured for 24 hours, then routine karyotype analysis was performed with R-banding technique. Interphase fluorescence in situ hybridization (FISH) and a panel of 5 probes, including CCND1/IgH, CEP12, D13S319, p53 gene and ATM gene, were used to investigate the cytogenetic features of the samples.</p><p><b>RESULTS</b>Chromosome aberrations were found in 9 (64.3%, 9/14) patients by conventional cytogenetics (CC), 8(57.1%, 8/14) patients had the aberration of t(11; 14), 6(42.9%, 6/14) had complex aberrant karyotypes, of which 2 (14.3%, 2/14) had highly complex aberrant karyotypes. A total of 28 abnormalities were detected, among them 19 (67.9%) were structural abnormalities, the other 9 (32.1%) were numerical aberrations. The aberration of t(11; 14) was found in all 18 (100%) patients with MCL by FISH. Secondary cytogenetic aberrations were detected in 14 patients by FISH. The most common abnormality was del(11q22.3) (57.1%), the rate of aberrations for del(17p13), + 12 and del(13q14) were 42.9%, 35.7% and 21.4%, respectively. Two (14.3%) and 4 (28.6%) patients were detected to have combinations of 2 and 3 aberrations.</p><p><b>CONCLUSION</b>In addition to t(11; 14), most MCL patients have other chromosome aberrations, especially complex aberrant karyotype.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Anomalias Congênitas e Cromossômicas
/
Linfomas e Mieloma Múltiplo
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Cromossomos Humanos Par 11
/
Cromossomos Humanos Par 14
/
Mortalidade
/
Aberrações Cromossômicas
/
Linfoma de Célula do Manto
/
Genética
/
Cariotipagem
/
Estadiamento de Neoplasias
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2011
Tipo de documento:
Artigo