Detecting microdeletions of the Y chromosome in patients with high follicle-stimulating hormone azoospermia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 485-487, 2004.
Article
em Zh
| WPRIM
| ID: wpr-328843
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the patients' high follicle-stimulating hormone (FSH) azoospermia and microdeletions in Y chromosome.</p><p><b>METHODS</b>Eleven sequence tagged sites (STSs) in Yq were detected by PCR in 16 male patients' high FSH azoospermia.</p><p><b>RESULTS</b>Microdeletions were observed in 6 of 16 male patients and the deletion rate was 37.5%(6/16). Five types of microdeletions were detected: AZFc(SY152), AZFc (SY152+SY254)+AZFd (SY153), AZFc (SY152+SY254+SY255)+AZFd (SY153), AZFc (SY152+SY158+SY255)+AZFd (SY153),and AZFb (SY130)+AZFc (SY158+SY254+SY255)+AZFd (SY153) respectively.</p><p><b>CONCLUSION</b>Microdeletion of Y chromosome was one of the important reasons of the patients' high FSH azoospermia. Before the application of assisted-reproductive technology (ART) to the patients, it is necessary to detect the microdeletions, especially AZFc and AZFd.</p>
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Base de dados:
WPRIM
Assunto principal:
Reação em Cadeia da Polimerase
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Sitios de Sequências Rotuladas
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Deleção Cromossômica
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Cromossomos Humanos Y
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Azoospermia
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Hormônio Foliculoestimulante
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Genética
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Infertilidade Masculina
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Metabolismo
Limite:
Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2004
Tipo de documento:
Article